Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 3

Wound healing potential of Biophytum sensitivum (L.) DC.: An ayurvedic drug


Non curative wounds is one of the major problems often encountered in health care system. The resumption of interest to use of Traditional System of Medicine especially plant based medicines is rapidly growing. Herbs are more potent healers and promote the repair mechanisms in a scientific way without causing any side effects. Plants used in Ayurveda are known to play significant role in the management of wound healing. But scientific evaluation of these herbal drugs to assess their safety and efficacy as well their standardization are required for their international recognition and acceptance. Hence in the present study attempts were made to scientifically evaluate the wound healing potentials of an ayurvedic plant, ‘LAJJALU’ botanically equated as Biophytum sensitivum (L.) DC. (BS). In this study wistar strain albino rats are used as animal model. The wound healing efficacy of the methanolic extracts of source taxon in 1g and 2g dose level was evaluated in excision wound models. The wound treated selected plant showed higher rate of wound contraction, increased level of Hydroxy proline, Hexosamine content, Super Dismutase, Ascorbic acid and decreased Lipid peroxidation. Histopathological studies revealed the presence of newly formed blood vessels amidst the well laid collagen fibres. Significant wound healing activity was observed in both the groups which were administered 1g and 2g of the test drug. But the animals treated with 2g revealed complete healing effect on 15th day.

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