A Simple, accurate and precise reverse phase high performance liquid chromatography (RPHPLC) method for the simultaneous estimation of Rosuvastatin Calcium and Telmisartan in marketed formulation is developed. The determination was carried out on a Inertsil ODS 3V C18 (250 x 4.6 mm, 5 µm) column using a mobile phase of Ammonium Dihydrogen Phosphate (pH 3) Buffer solution: Methanol (65:35v/v, pH 3.0). The flow rate was 1.5 ml/min with detection at 298 nm. The retention time for Rosuvastatin was 6.1 min and for Telmisartan 16.2 min. Rosuvasatin Calcium and Telmisartan showed a linear response in the concentration range of 6- 18 µg/ml 24-72 µg/ml respectively. The correlation co-efficient (' r ' value) for Rosuvastatin Calcium and Telmisartan was 0.9986 and 0.9961 respectively. The results of analysis have been validated as per ICH guidelines and by recovery studies. The percentage recoveries obtained for Rosuvastatin Calcium and Telmisartan ranges from 100.04 to 100.57%.