A simple, specific, accurate and precise reverse phase high pressure liquid chromatographic method has been developed for the simultaneous determination of Lornoxicam and Thiocolchicoside from tablets by reverse phase C18 column (Inertsil ODS 3V C-18, 250 x 4.6 mm, 5 µ). The sample was analyzed using Buffer(5.7606 gm Ammonium Dihydrogen Phosphate in 2000mL of milli-Q water, adjust pH 7.3 with Tri Ethyl Amine): Methanol in the ratio of 45:55, as a mobile phase at a flow rate of 1.5 mL min-1 and detection at 290 nm. The retention time for Lornoxicam and Thiocolchicoside was found to be 9.40 and 2.96 min respectively. The method can be used for estimation of combination of these drugs in tablets. The method was validated as per ICH guidelines. The linearity of developed method was achieved in the range of 0.24 – 120 µg mL-1 (r2 =0.9999) for Lornoxicam and 0.235 – 120 µg mL-1 (r2 =0.9999) for Thiococlchicoside and recoveries from tablets were between 100 and 102%. Due to these attributes, the proposed method could be used for routine quality control analysis of these drugs in combined dosage forms.