A simple, rapid and sensitive spectrophotometric me thod for the determination of silymarin- flavonolignans (a compound from Silybum marianum ) in pure form and in pharmaceutical formulations is described. The method is based on t he simple solubility of silymarin in methanol. The absorbance maximum of silymarin measu red at wavelength 287nm. The drug obeys Beer’s Law in the concentration range 6-16
g/ml employed for this method. Accuracy and reproducibility of the proposed method was stat istically validated by recovery studies. The method is found to be rapid, precise and accura te and can easily be employed in the laboratory for the routine estimation of drug and i t’s extended to the analysis of silymarin in pharmaceutical formulations.