An efficient route to manufacture sodium percarbonate by using ethanol as the solventing-out agent is researched. The process conditions were optimized by means of multiindex uniform design and multiple regression method. Two models to express the effect of factors on active oxygen and yield of sodium percarbonate were established, respectively. The final optimized conditions are as follows: temperature 20℃, reaction time 1h, mole ratio of H2O2:Na2CO3 1.4, stabilizer molar ratio of sodium silicate: Ethylenediaminetetraacetic acid disodium salt 2:1, amount of stabilizer 1%. IR and XRD identification denote that the major component of the prepared product is Na2CO3·1.5H2O2. The photomicrograph indicates a majority of the obtained product crystals are club-shaped.