Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2012 Vol: 4 Issue: 3

Trizma: Efficient catalyst and reactant in Knoevenagel condensation reaction under conventional heat and microwave irradiation conditions


Knoevenagel condensation of several aromatic aldehydes 1 with different active methylene compounds 2 under conventional heat condition was efficiently mediated by TRIZMA as a benign catalyst to afford the corresponding arylidenes 3 in excellent yield. In the same reaction the yield has dramatically reduced when microwave irradiation was employed under nitrogen while when the irradiation has carried out in presence of oxygen air TRIZMA showed an extraordinary reactivity and N1-(1,1-diethylpropyl)-N2-(1-ethyl-1-hydroxymethylpropyl) ethanediamide 4 was obtained instead.