Nature’s beauty in terms of health care is appreciated by developing various systems of traditional system (Ethnomedicine). There is growing focus on the importance of medicinal plants in the traditional health care system in solving health care problems. The demand for herbal products is growing exponentially throughout the world. Finding healing power in plants is an ancient idea. Recently there has been a shift in universal trend from synthetic to herbal medicine, which we can say Return to Nature’. Medicinal plants have been known for millennia and are highly esteemed all over the world as a rich source of therapeutic agents for the prevention of diseases and ailments. Tephrosia purpurea (TP) is a species of flowering plant in the pea family, Fabaceae, a common wasteland weed and grows in poor soils. TP has played an important role in the traditional medicine. Thus, the modern pharmacological and clinical investigation of TP is a valuable herbal therapy that has an antioxidant, antimicrobial, anti-inflammatory, anti-viral and antiulcer properties. Overall, several properties appears to be the most promising pharmacological effect of TP. However, the lack of a detailed ethnopharmacological, pharmacological and phytochemical analysis of TP is an important limitation. Thus, there is a need of further research to explore the meaningful properties of TP. However, review of this paper enlightens the ethnopharmacological, pharmacological, modern pharmaceutical uses of TP.