Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Reviews: 2016 Vol: 8 Issue: 12

Therapeutic Aspects of Sulfonylureas: A Brief Review


Sulfonylureas are a class of organic compounds used in medicine and agriculture. All pharmacologically active sulfonylureas contain a central S-aryl sulfonylurea structure with a p-substituent on the phenyl ring and various groups terminating the urea N′ end group. Chemically, this functionality can be easily installed by reacting aryl sulfonamides with isocyanates. The current survey focused on some well-established method for preparation of sulphonylurea followed by their pharmacological profile. It is primarily used for the treatment of diabetes mellitus type 2 a pancreatic disorder. Though It also has some extrapancreatic effect like anti-cancer, diuretic, anti-inflammatory, anticonvulsant and neuroprotective agents etc which is discussed in our paper.