In this review we have explored the various alternatives that are being developed and explored for the effective control, prevention, and treatment of Dengue fever. Dengue fever affects approximately 2.5 billion people or half the world’s population. Specifically, in the Tropics regions, it has acquired an endemic proportion. As a consequence, the search for alternative approaches for the prevention of dengue has assumed more urgency than in the past. Environmental measures for source reduction, use of vaccines, for mass immunization of population in endemic regions, and biological vector control measures are being extensively researched for advanced dengue prevention. Phytochemicals are also been explored in order to develop a bioactive molecule effective against vector-borne viral infections.