Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 10

The study of rheological properties of the fatty ointment base for topical treatment of colds

Abstract

In developing of ointment for topical treatment of colds the structural and mechanical properties of t he ointment bases contained isopropyl palmitate, beeswax and so lid fat in different concentrations have been studi ed. Amount of isopropyl palmitate 60% remained constant and the r atio of solid fat and bee wax was varied. In order to study thixotropic properties the curve of kinetics deform ation of ointments has been constructed. It has bee n set that when increasing solid fat content in ointment compositio n and respectively decreasing beeswax the structura l and mechanical properties of the base are reduced. The tested ointment bases possess thixotropic propertie s and plasticity and belong to the class of Bingham syste ms. Thus ointment with solid fat content of 8%, iso propyl myristate of 60% and beeswax of 32% is superior by its rheological characteristics to other formulatio ns.