Knowledge-based talents with advanced knowledge, experience and skills are major creators of enterprise value.A study on the various reasons causing the flow risks of knowledge-based talents is of great theoretical and practical significance. The article begins with a review of research literature, and then analysis on formation factors of knowledge-based talents’flow risk, through empirical study found that personal factors, organizational factors, team factors and environmental factors, includingjob interest,work ability, recognition of the work, working conditions, compensation and benefits, promotion prospects, relationshipwith superiors and colleagues, individual effort, economic and social environmentare the critical factors of knowledge-based talentsflowrisk in China.