Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2018 Vol: 10 Issue: 8

The Influence of Nitro Group on Synthesis of (E) 1-(4-Methoxyphenyl)-3-phenylprop-2-en-1-on Derivatives via Claisen-Schmidt Condensation

Abstract

The aim of this research was to compare the synthesis of chalcone derivatives via Claisen-Schmidt condensation reaction between 4-methoxyacetophenone (1) with nitro-substituted benzaldehydes (2a-c) by conventional method and microwave irradiation assistance. The synthesized compounds were analyzed using TLC, melting point, IR and 1H-NMR spectroscopy. The yield obtained of 4-methoxychalcone (4a) by conventional method and microwave irradiation assistance were 84% and 53% respectively. The reaction between 4-methoxyacetophenone and 4-nitroor 2-nitro-benzaldehyde by conventional method formed 3-hydroxy-1-(4-methoxyphenyl)-3-(4-nitro-phenyl)propan- 1-one (3b) and 3-hydroxy-1-(4-methoxyphenyl)-3-(2-nitrophenyl)propan-1-one (3c); the yield were 82% and 59% respectively. The presence of nitro substituent at para and ortho position on benzaldehyde caused chalcone derivative compound had not been formed yet.

http://sacs17.amberton.edu/

rtp slot demo