CNS disorders have been estimated approximately up to 20% of the nationwide cost of healthcare in the developed countries, Because of various socioeconomic problem in developed as well as developing country the number of patient related to psychological disorder are increasing day by day. Various survey projections indicate that sales of drugs to treat neurological diseases and other CNS drugs will approach more that $70 billion and that expected to approach up to $ 225 billion in next five years reflecting an absence of effective treatments for another years. The current review is focused on the account of six membered saturated ring containing nitrogen heteroatom. Of which many of the successful drugs are having piperazine and piperidine ring as pharmacophore.