The use of medicinal plants has gained more importance because of its natural origin and high therapeutic significance. The various species of the genus Mussaenda has many novel phytochemical constituents which has high pharmacological activities such as anti- inflammatory, antioxidant, antimicrobial etc. useful for the treatment of many health disorders. This review describes the importance of the genus Mussaenda and various experimental research carried out in different species of this genus which will provide information to develop a new herbal drugs.