In the present study Murraya koenigii commonly called “curry leaf” leaves extracts subjected to a screening study to detect potential antimicrobial activity against Strains of Escherichia coli, Bacillus cereus, Staphylococcus aureus, Bacillus subtilis Klebsiella pneumonia, Staphylococcus epidermidis, Pseudomonas aeruginosa, Staphylococcus faecalis, Vancomycin resistant enterococcus and Candida albicans. The antibacterial activity of the products was evaluated using colonies growing in solid medium, establishing the zone of inhibition in vitro growth (ZOI). Plant (leaf) extract was also used for the phytochemical tests for compounds which include Glycosides, Steroids, Tannins, Alkaloids, Flavonoids, Saponins, Quinone, Protein and Sugar in accordance with the methods. The results showed that most of the bacterial strains (except E. coli, B. cereus and S. faecalis) had intermediate effect at low concentration leaf extract (10 and 15%) of Murraya koenigii but the efficacy of the leaf extract could be increased by increasing the concentration of the extract.