Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2016 Vol: 8 Issue: 8

The effects of mallow�¢����s hydro alcoholic extract on reducing the anxiety caused by convulsion in mice

Abstract

Convulsion is a limited brain event due to abnormal discharge of brain neurons which is still a medical challenge despite medical advances. Anxiety is a natural feeling that is experienced in threatening situations. Anxiety patients use benzodiazepines constantly which have side effects. This study was carried out to investigate the effects of mallow’s hydro alcoholic extract on reducing the anxiety caused by convulsion. Forty mature mice from Balb/C race were randomly divided into five groups: Control, pentylenetetrazole and 50, 100 and 200 mg/kg doses of extract. The extract was injected intraperitoneally. Convulsion was enforced using pentylenetetrazole 65 minutes before injection. Evaluation was done using elevated plus maze and remaining times in closed and open arms were analyzed using variance analysis and Duncan test. According to results, pentylenetetrazole reduced the activity, the percentage of open arm entries, and time spent in the open arms significantly. Activities of all experimental groups were normal (about control group). The percentage of open arm entries was normal (about control group) for 100 and 200 groups. Mice of 200 mg/kg group were more willing to stay in open arms in proportion to control group. So, ethanol extract of Mallow in 200 mg/kg dose can reduce the anxiety of PTZ-induced convulsions.