Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2016 Vol: 8 Issue: 2

The effects of frankincense?¢????s hydro alcoholic extract on pituitary-gonadal axis in female mice


Frankincense, is a resin obtained from Boswellia carteri plant. Previous researches have shown medicinal effects of this resin on wide range of diseases. This study was carried out to investigate the effects of frankincense’s hydroalcoholic extract on pituitary-gonadal axis of mice. Mice were divided into five groups including control, placebo, and three experimental groups with 10 members in each group. Control group did not receive any drug and experimental groups received intraperitoneal injections of 50, 100, and 200 mg/kg of the extract for 20 days every other day. Blood samples were taken at the end of injection period. FSH, LH, estrogen and progesterone hormones were measured. Obtained results were analyzed using SPSS program in a one way analysis of variance and means were compared using Duncan test at 5% probability level. According to results, LH and FSH amounts were decreased by increasing the estrogen. Considering the results, frankincense extract can affect female mice reproduction system dose dependently and can have antifertility properties.