Hospital sewage treatment and disinfection has become a public problem that often directly affects the public security and environment health. The economical and applicable technology including combined technology for hospital sewage treatment has become research hotspot. In this paper, pipeline-disinfection for hospital sewage treatment was proposed to replace contact disinfecting tank, the practical difficulty of no space to build contact disinfecting tank can be solved. It also can ensure the most optimal retention time. The combined process for hospital sewage treatment of three-stage filtration system and chlorine dioxide disinfection, which is suitable for the disinfection for hospital sewage of small or township hospital was adopted. The results showed that the three-level filtration system can effectively remove suspended solids, COD and BOD, and the preparation of chlorine dioxide on the spot can achieve better disinfection effect, also won't produce large quantities of disinfection by-products. The study will provide scientific reference and basis to improve the design parameter of treatment technology for the engineering application of disinfection system for treating hospital sewage.