Introduced the latest application of biomedical polymer material Hydroxypropyl methyl cellulose (HPMC) in pharmaceutical preparations. An extensive search was performed within PubMed, MEDLINE, CNKI, Vipand Wan-Fang up to March 2014.Based on the analysis and induction, and elaborated it in the application of solid preparation, liquid pharmaceutical, sustained-controlled preparation, capsule formulations, gel preparation and bio-adhesion preparation. HPMC can be widely used and will play a greater role in the field of pharmaceutical preparations.