The purpose of this research was to mask the intensely bitter taste of Ondansetron HCl and to formulate a Fast dissolving tablet (FDT) of the taste-masked drug. Taste masking was done by complexing Ondansetron HCl with aminoalkyl methacrylate copolymer (Eudragit EPO) in different ratios by the extrusion method and Novel wet granulation method. Taste masked complex were analyzed with FTIR, DSC and XRD. Drug-polymer complexes (DPCs) were tested for drug content, in vitro taste in simulated salivary fluid (SSF) of pH 6.8, and molecular property. In vitro release profile obtained at SSF pH 6.8 indicate that perceivable amount of drug will not be released in saliva. The taste masked granules were directly compressed in to tablets using crosscarmellose sodium (Ac-Di-Sol) as a super disintegrantes. Tablets of batch F4 containing microcrystalline cellulose and lactose in the ratio 1:1 and 6% wt/wt Ac-Di-Sol showed faster disintegration, within 34 seconds, than the marketed tablet (102 seconds). . Tablets of batch F4 also revealed rapid drug release (t90, 240 seconds) at acidic pH 1.2 of the stomach compared with marketed formulation (t90, 600 seconds). The observed polymer interaction and reduced crystallinity may be reason for increased dissolution rate. Thus, results conclusively demonstrated successful masking of taste and rapid disintegration and dissolution of the formulated tablets.