Taste masking has gained immense significance in the formulation of bitter taste medicaments and is being tackled early in the product development to offer multiple benefits to both the patients as well as the pharmaceutical manufacturers. Taste masking is a viable and practical strategy to improve the patient compliance, especially for bitter drugs, whereby, a number of methodologies may be adopted to deliver a taste masked palatable formulation. Various techniques based on different principles have been investigated and described in academic and patent literature for masking of bitter or undesirable taste of drugs like addition of flavors, sweetener and amino acids, microencapsulation, complexation with cyclodextrins, complexation with ion exchange resin, salt preparation, group alteration and prodrug approach. In the present review, the spray drying has been presented as a viable technique for taste masking of bitter pharmaceuticals. The manuscript comprehensively describes the spray drying methodology, its instrumentation, characterization and application in pharmaceutical taste masking.