Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 3

Synthesis?¸ structural characterization, molecular modelling and antimicrobial studies of transition metal complexes of schiff base ligand derived from 5-chlorosalicylaldehyde and 2-(2-aminophenyl) 1H-benzimidazole

Abstract

A series of Ni(II), Co(II), Cu(II),and VO(IV) complexes have been synthesized from the Schiff base ligand.The Schiff base ligand is(2-[(Z)-{(2-(1H-Benzimidazole-2yl)phenyl]imino} methyl] – 4 - Chloro phenol(-BMCP) has been synthesized by the reaction between 2-(2-Aminophenyl)1- H-Benzimidazole and 5- Chloro Salicylaldehyde. The resulting complexes were characterized by elemental analysis, magnetic moment measurements, conductivity measurements, IR, UV-VIS , 1H NMR, mass spectra, and ESR spectral studies. All the complexes were tested for their antibacterial activity. From the data, an octahedral geometry around the central metal ion has been suggested for all the metal complexes except Cu(II) complex ,which has square planar geometry. Antimicrobial activity of the ligand and its metal complexes were studied against two gram negative bacteria: E.Coli, Pseudomonas.flourescence, and two gram positive bacteria: Bacillus.subitilis, Staphylococcus.aureus.The activity data show that the metal complexes are more potent than the free ligand.