Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2016 Vol: 8 Issue: 10

Synthesis, Structural Characterization and DNA Studies of Nickel (II) Complexes of (2E)-4N-Substituted-2-[4-(propan-2-yl) Benzylidene]Hydrazinecarbothioamide Schiff�¢����s Bases

Abstract

This paper describes the synthesis of nickel (II) complexes of (2E)-4N-substituted-2-[4-(propan-2-yl)benzylidene]hydrazinecarbothioamide Schiff bases derived from 4N substituted thiosemicarbazides and cuminal. The prepared ligands and complexes were characterized using various physicochemical techniques viz. elemental analysis, molar conductance, magnetic susceptibility measurements, IR, electronic absorption spectral studies and cyclic voltammetry. The spectral data indicates that the complexes are square planar geometry in solid state while in coordinating solvents like DMSO solvent exhibits octahedral geometry suggesting coordination of solvent molecules presumably in axial position. The absorption titration studies revealed that each of these complexes is an avid binder to calf thymus-DNA. The apparent binding constants are in the order of 107–108 M-1. The nucleolytic cleavage activities of the ligands and their complexes were assayed on pUC18 plasmid DNA using gel electrophoresis in the presence and absence of H2O2. The ligands showed increased nuclease activity when administered as copper complexes. All these nickel (II) complexes behave as efficient chemical nucleases with hydrogen peroxide activation. These studies revealed that the complexes exhibit both oxidative and hydrolytic chemistry in DNA cleavage.