Schiff base derivatives of N-(1Z)-[((mono or di-substituted aryl)-1,3-diphenyl-1H-pyrazol-4-yl) methylene]-4,6- dimethoxy pyrimidine-2-amine were synthesized by the acid catalyzed condensation of (mono- or di- substituted aryl)-1,3-diphenyl- 1H-pyrazole-4-carbaldehyde derivatives with 4,6-dimethoxy-2- amino pyrimidine. Schiff base derivatives were characterized by FT-IR, 1H-NMR, Mass spectral analysis and elemental analysis. All the synthesized compounds have been screened for their antimicrobial activities by using broth dilution method.