Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2014 Vol: 6 Issue: 6

Synthesis, spectral and antimicrobial studies of tetraazamacrocyclic complexes of bivalent transition metal ions of bioinorganic relevance


Eight new tetraazamacrocyclic complexes of the types [M(C32H24N8O4).2H2O] (CH3COO-)2 and [M(C14H20N8O4).2H2O](CH3COO-)2 , where M= Co (II)/ Ni (II) / Cu (II) /Zn(II), have been synthesized by the reaction of oxaloyldihydrazide and benzyl / acetylacetone by adopting template method. All the synthesized compounds were characterized by running their TLC for single spot, elemental analyses, infrared spectral studies, 1H-NMR spectral studies, magnetic susceptibilities measurements and electronic spectral studies. The elemental analyses and spectral analysis results revealed their Metal: Ligand (1:1) stoichiometry. Magnetic moment values and electronic spectral studies suggested octahedral geometry for Co (II), Ni (II) complexes while distorted octahedral geometry for Cu (II) complexes. Synthesized dihydrazide and all macrocyclic complexes were screened for antimicrobial activity against two bacteria Staphylococcus aureus and Escherichia coli and two fungi Aspergillus niger and Aspergillus flavus. ODH-AA Cu (II) complexes was found most active against both bacteria while ODH-AA Zn (II) complex was most active against both fungi.

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