New series of fatty chain derivatives ofbenzoxazinones and quinazolinones have been synthesized from the two simple precursors of palmitoyl acid chloride and anthranilic acid. Antibacterial and anti-fungal inhibition effect of all products has been investigated. Compounds1, 3, 8, 12 and 15 showed high inhibitory effect towards gram negative and gram positive bacteria while compounds3, 6 and 7 exhibitedhigher anti-fungal effect. The structure of all products has been characterised by IR, NMR, Mass spectra and elemental analyses.