Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 1

Synthesis pterocarpan compounds from Erythrina crista-galli L and their action towards Plasmodium falciparum


Synthesis of the naturally occurred 3-acetyl sandwicensin(2) and 2,7- dibromosandwicensin(3)was carried out by acetylation and bromination reaction, respectively. The pterocarpan synthesized in this study was andwicensin(1) isolated from stem bark of Erythrina crista galli L. Their structures were established on the basis of spectroscopic evidence. Compounds 1–3 were evaluated for their antimalarial properties against Plasmodium palcifarum, showing their IC50 were 1.83, 34.81 and 12.9 μg/mL, respectively.