Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2012 Vol: 4 Issue: 8

Synthesis of some novel Isoxazole, Cyanopyridine and Pyrimidinthione derivatives


A new series of isoxazoles (7a-d), cyanopyridines (8a-d) and pyrimidinthiones (9a-d) have been prepared from chalcones (6a-d) having s-triazine nucleus. These chalcones on cyclisation with hydroxyl amine hydrochloride in the presence of alkali and malononitrile in the presence of ammonium acetate give isoxazoles (7a-d) and cyanopyridines (8a-d) respectively. Chalcones (6a-d) on condensation with thiourea in the presence of alkali give pyrimidinthiones (9a-d). Structures of newly synthesised compounds were established on the basis of their elemental analysis, IR and 1H NMR spectral data.