Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2015 Vol: 7 Issue: 3

Synthesis of some new sulfonamide derivatives based on 1,3,4-oxadiazole

Abstract

In the present work a variety of new heterocyclic compounds namely hydrazide, oxadizole, β-lactam, aza-β-lactam were synthesized by Sequential reactions started from alkylation of Sodium saccharin salt by different alkyl halides namely benzyl chloride, n-propyl bromide and sec-butyl bromide than hydrolysis the N-alkyl saccharin derivatives(1a-c)using 10% NaOH to give the N-alkyl sulfamidobenzoic acid derivatives(2a-c).Reaction (2a-c) with ethyl alcohol in presence Conc. sulfuric acid give the corresponding ester derivatives (3a-c). The benzohydrazide derivatives (4a-c) were obtained via reaction of ester derivative with 80% hydrazine hydrate. The cyclization of (4a-c) with carbondisulfide in presence potassium hydroxide gave the corresponding 2-mercapto-1,3,4-oxdiazol derivatives(5a-c). Reaction of (5a-c) with 80% hydrazine hydrate gave 5-hydrazido 1,3,4-oxadiazol derivatives(6ac). The Schiff bases(7a-f) were obtained by condensation of (6a-c) with 2,4-dimethoxybenzaldehyde and pdimethylaminobenzaldehyde. The cyclization of (7a-f) with chloroacetyl chloride and phenylisocynate gave the corresponding β-lactam (8a-f) and aza-B-lactam(9a-f) derivatives. F.T.IR and 1-HNMR were used to characterize the target compounds.

http://sacs17.amberton.edu/

rtp slot demo