Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 8

Synthesis of some new analogs of quinoline containing imine bond form the initial composition of aniline


A number of new derivatives quinoline were synthesized using of the Vilsmeier–Haack reagent (DMF+ POCl3). To this end ,the initial composition of aniline after the acquisition of a group methyl- ketone (1) , gave the fused pyridine ring by cyclization and a free aldehyde group is made (2) . Finally , after using aryl-amine derivatives one type, made imine bond connection to the qoinolineis (3) . final products were supported by FTIR, 1H NMR and Mass spectroscopic measurements and possess moderate to good antibacterial and antifungal activities.