A number of new derivatives quinoline were synthesized using of the Vilsmeier–Haack reagent (DMF+ POCl3). To this end ,the initial composition of aniline after the acquisition of a group methyl- ketone (1) , gave the fused pyridine ring by cyclization and a free aldehyde group is made (2) . Finally , after using aryl-amine derivatives one type, made imine bond connection to the qoinolineis (3) . final products were supported by FTIR, 1H NMR and Mass spectroscopic measurements and possess moderate to good antibacterial and antifungal activities.