Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2014 Vol: 6 Issue: 6

Synthesis of S-alkyl/S-benzyl-1,4-dihydropyrimidines and evaluation of their biological activity


Dihydropyrimidines are associated with wide range of biological activities. Keeping this in view 6-phenyl-4- substituted phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid ethyl ester were prepared under microwave irradiations. These were converted to S-alky/S-benzyl-1,4- dihydropyrimidines for synthesizing biologically active molecules with improved activity. These are regarded as aza-analog of nifedipine. These compounds were screened for their anti-hypertensive activity. All the synthesized compounds have been characterized on basis of their spectral data

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