Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 4

Synthesis of Novel Mutual Pro-drugs by coupling of Ibuprofen (NSAID) with Sulfa drugs


Non-steroidal anti-inflammatory drugs (NSAIDs) commonly used for the treatment of chronic inflammatory diseases suffering from several undesired side effects, the most important being gastrointestinal (GI) irritation and ulceration. The Pro-drug designing is one of the several strategies used to overcome this drawback. However, mutual pro-drug concept also can be exploited for this purpose. The mutual Pro-drug consists of two pharmacologically active agents coupled together covalently so that each acts as promoiety for the other agent and vice-versa. Since an infection always leads to inflammation. Therefore sulfa drugs can be coupled with NSAIDs as amide derivatives of NSAIDs. In this way the carrier drug (sulfonamides) may be useful to overcome some side effects of parent drug particularly gastrointestinal (GI) irritation. In this paper we wish to report simple procedure to couple Ibuprofen with various sulfa drugs to get amide derivatives. So that these mutual pro-drugs may be used for infection as well as for inflammation.