Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 8

Synthesis of new triazole and oxadiazole containing compound in the azide reaction as an antibacterial drug


Triazole-containing compounds or oxadiazole as anti-bacterial always be used in pharmaceutical science. So our went to produce compound to be including both the imidazole and oxadiazole. pyridine-3-carbohydrazide (4) reaction with chloroacetic acid in presence of POCl3 gave chloro methyl 1, 3, 4 –Oxadiazole (5) derivative. Compound (5) on treatment with sodium azide yielded azidiomethyl- 1, 3, 4-oxadiazole (6). This azide (6) derivative further reacted with acetyl acetone in presence of potassium carbonate to form 1-(1-((5-pyridin-3-yl)-1,3,4- oxadiazol-2-yl) methyl)-5- methyl-1H-1,2,3-triazol-4-yl)ethanone (7).

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