Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2013 Vol: 5 Issue: 3

Synthesis of N-arylamines in dry media and their antibacterial activity


A number of N-arylamines have been synthesized by carrying out N-arylation of primary/secondary amines with activated aryl halides in presence of KF/Al2O3 (basic) dry media at room temperature. All the new compounds have been characterized by their spectral and micro analytical data. Compounds were examined for their antibacterial activity against Escherichia coli, Salmonella typhi, Bacillus substilis, and Staphylococcus aureus. Some of the synthesized compounds showed significant anti-bacterial activity.