Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2017 Vol: 9 Issue: 6

Synthesis of Highly Functionalized Pyrazoles Using AlCl3 as Catalyst


An easy and simple three-component one-pot process for the synthesis of 5-amino-1,3-diphenyl-1H-pyrazole-4-carbonitrile derivatives using aldehyde, phenylhydrazine and malononitrile has been developed. The method gave 79 to 89% yields in a maximum of 30 minutes using AlCl3 as catalyst in aqueous ethanol (1:1 v/v).