The environment-friendly one-pot three-component condensation reactions of N, N- dimethylbarbituric acid or 1, 3-indandione, aldehyde and cyclohexyl isocyanide to afford furo[2,3-d]pyrimidine and indeno[1,2-b]furan derivatives in water using microwave irradiation in good yields after about 10-12 min are reported.