Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 4

Synthesis of Aspirin Prodrugs of ?Ž?²-Cyclodextrin on the Primary/Secondary Hydroxyl Sides


Aspirin was covalently conjugated to the primary/secondary hydroxyl groups of β-cyclodextrin in different solvents using different reagents for acylation. In pyridine, β-cyclodextrin reacted with acetylsalicylic acid chloride to produce the aspirin conjugates on the primary hydroxyl side, and in a carbonate buffer solution of N, N-dimethylformamide, β-cyclodextrin reacted with N-(2-acetoxybenzoyl)imidazole to give the aspirin conjugates on the secondary hydroxyl side.