Six Potential Tridentate Chiral Schiff base ligands and its metal complex were synthesized and characterized, in that the amino alcohol and 2-amino-3,5-dibromobenzaldhehyde were linked by C=N bond, which can be complexes with metal acetate especially copper and nickel acetate, it has Antibacterial activity against several microbes have been tested and found all six compounds exhibits potential antibacterial activity.