Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 7

Synthesis of 2-phenyl-3H-dipyrimido[1,2-a] pyrimidin-4(5H)-one derivatives and their antifungal activity


Some 2-phenyl 3H-dipyrimido[1,2-a] pyrimidin -4(5H)-one derivatives were synthesised by the reaction of pyrido[1,2-a]pyrimidine 3-carbonitrile with benzoic acid in the presence of catalytic amount of Amberlyst 15–wet (strongly acidic) in green reaction medium i.e. PEG-400. The structural elucidation of the compounds was performed by spectral analysis. All the synthesized compounds were screened for their antifungal activity. Most of compounds show excellents activity .