The chemistry of pyrimidines is a blossoming field for the study of their pharmacological uses. Numerous methods for the synthesis of 1,2,3,4-tetrahydro pyrimidine as also their diverse reactions offer enormous scope in the field of medicinal chemistry. Keeping in mind various biomedical applications and with a view to further asseaa the pharmacological profile of these class of compounds, novel 1,2,3,4-tetrahydro-N-(substituted phenyl)- 6-methyl-2- oxo-[(4-(phenoxy)-methyl) phenyl] pyrimidine-5-carboxamide(AB101 to AB115) are synthesizes. The products were characterized by FT-IR, 1H NMR, Mass spectra and elemental analysis. The newly synthesized compounds were subjected to antimicrobial activities.