Quinzolinones have various biological activities such as anticancer, antidiabetic, anticonvulsant, antihistaminic, anti-inflammatory, antifungal, anthelmintics and antiviral activites. In this research some of compounds 2,3-disubtitutedquinazolin-4(3H)-one derivatives had been synthesized under microwave irradiation. The compounds were obtained from reaction some of benzoxazine derivatives with hydrazine hydrate using microwave irradiation and the result of reaction we obtained 82-96%. The productshad been tested by IR, 1H-NMR, 13C-NMR and Mass Spectroscopy analysis. The using microwave irradiation was more effective and efficient to produce compounds 2,3-disubtituted quinazolin-4(3H)-one derivative because the reaction runs perfectly without any minor products such as compounds N-(2-(hydrazinecarbonyl)phenyl)benzamide derivatives.