Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 6

Synthesis Design of ?¢????Rivastigmine?¢????-A Potent Therapeutic Agent for Alzheimer?¢????s disease using Retrosynthetic Analysis


Synthesis is an indispensable component in the multidisciplinary development process of small molecule pharmaceuticals. Designing synthetic routes to the pharmaceuticals by retrosynthetic analysis /synthon disconnection approach, developed by Prof.E.J.Corey of Harvard University has emerged as powerful means in synthetic organic/medicinal chemistry. Keeping a bird’s eye view on the works published in journals and patent literatures, some synthesis schemes have been proposed for a potent Alzheimer’s disease drug ‘Rivastigmine’ in a novel way basing on the retrosynthetic analysis. The proposed synthesis planning being a theoretical exploration, the actual laboratory execution requires the cross examination of a considerable number of factors such as reactions, reagents and order of events. In actual practice, generally that route is most feasible which satisfies the specific criterion for an ideal synthesis.

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