Original Articles: 2012 Vol: 4 Issue: 6
Synthesis Design of Ã?¢Ã?â?¬Ã?Ë?RivastigmineÃ?¢Ã?â?¬Ã?â?¢-A Potent Therapeutic Agent for AlzheimerÃ?¢Ã?â?¬Ã?â?¢s disease using Retrosynthetic Analysis
Abstract
Synthesis is an indispensable component in the multidisciplinary development process of small molecule pharmaceuticals. Designing synthetic routes to the pharmaceuticals by retrosynthetic analysis /synthon disconnection approach, developed by Prof.E.J.Corey of Harvard University has emerged as powerful means in synthetic organic/medicinal chemistry. Keeping a bird’s eye view on the works published in journals and patent literatures, some synthesis schemes have been proposed for a potent Alzheimer’s disease drug ‘Rivastigmine’ in a novel way basing on the retrosynthetic analysis. The proposed synthesis planning being a theoretical exploration, the actual laboratory execution requires the cross examination of a considerable number of factors such as reactions, reagents and order of events. In actual practice, generally that route is most feasible which satisfies the specific criterion for an ideal synthesis.