Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 6

Synthesis, Charecterisation and biological Evaluation of Novel Hantzsch 1,4-dihydropyridines


We report a library consisting of some novel Hantzsch dihydropyridines of biological interest as well as their synthesis and analysis. The important steps in the synthetic part were found to be Hantzsch reactions. The synthesized compounds were screened for their in vitro antibacterial activity against two gram-positive bacteria: Staphylococcus aureus and Bacillus subtilis. The title compounds did not exhibit potential antibacterial activity. Furthermore, compounds were subjected to in vitro cytotoxicity against Vero cells. Compounds exhibited weak, moderate, or high cytotoxicity. Compounds 9b, 9c, 9d, 9e, 9f, 9g exhibited potential cytotoxicity.

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