Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 1

Synthesis, characterization of 4{[(7-chloro-2-nitro phenothiazine-10-yl)-phenyl-methyl]-amino}-benzoic acid derivatives


In this work,we reported the synthesis of Phenothiazine derivatives. Phenothiazine (I) was synthesized by reacting diphenylamine, sulfur, and iodine which subsequently reacted with thionyl chloride and dry benzene is added dropwise to form 2-Chloro 10H- Phenothiazine(II). 2- Chloro 10H- Phenothiazine(II)further reacted with Nitric acid and Con Sulfuric acid by the Nitration Process to form 2-Chloro 7-Nitro10H- Phenothiazine(III).Then2-Chloro 7-Nitro10HPhenothiazine( III) was reacted with Para-amino benzoic acid with different Aromatic Benzaldehyde under refluxing condition then it form the final product. The yield of novel compound was recorded 46-85%. All compounds were characterized on the basis of Melting point, I.R spectra, N.M.R spectra and MASS spectra.

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