Keeping in view of the varied biological activities of chalcones and their heterocyclic analogues, various arylfurylpropenones were prepared by the condensation of substituted arylfurfuraldehydes with various suitably substituted acetophenones by Claisen-Schmidt condensation reaction. All the newly synthesized compounds were characterized by elemental analysis and spectral studies. The common mass spectral fragmentation patterns are presented here. These compounds were also tested for their antibacterial activities.