A series of La(III), Pr(III), Nd(III), Sm(III), Eu(III), Gd(III), Tb(III), Dy(III) and Yb(III) complexes have been synthesized with the Schiff base (PHC) derived from the condensation of 8- formyl-7-hydroxy-4-methyl-coumarin with 3-amino pyridine. The prepared Schiff base and their lanthanide complexes have been characterized by elemental analysis, molar conductance, magnetic susceptibilities electronic, IR, 1H-NMR, ESR, FAB-mass and thermal studies. The complexes have stoichiometry of the type [Ln(PHC)2(NO3)(H2O)2].2H2O, where the ligand PHC coordinates to the lanthanide ion through azomethine nitrogen and phenolic oxygen of coumarin moiety via deprotonation .The Fluorescence properties of the synthesized compounds have also been studied. The compounds have been screened in vitro for antibacterial and antifungal activities. Active compounds have been assayed with MIC values. The antitubercular activities for the compounds have been carried out against, H37Rv Strain by middle Brook Method. The brine shrimp bioassay was also carried out to study the in vitro cytotoxicity properties for the ligand and their corresponding complexes.