Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 10

Synthesis, characterization and pharmacological evaluation of some 1,4-dihydropyridines derivatives


A series of 1, 4-dihydropyridine derivatives were p repared from three compounds condensation reaction of ethylacetoacetate, aromatic aldehyde and ammonium h ydroxide. A new series of compounds (2a-f) were pre pared from compounds (1a-f) via reaction with β -naphthayl amine using the condensation method. The synthesized compounds were confirmed by IR, 1 H NMR, 13 C-NMR and Elemental analyses. The synthesized compo unds (1e-f) and (2a-f) were also screened for antimicrobial pro perties.