Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 8

Synthesis, Characterization and Molecular docking of Bi and Tridentate Chiral molecules for HIV-Native protease

Abstract

Six potential Bi and Tridentate chiral molecules were synthesized and characterized, in that the amino ester and 2- amino-3,5-dibromobenzaldhehyde were linked by C=N bond which can be specifically reduced using Tetrabutylammonium borohydride and ester further convert into Alcohol using lithium borohydride. The synthesized compounds are evaluated for molecular docking to check potency of the synthesize compounds for HIV-protease.