Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2013 Vol: 5 Issue: 6

Synthesis, characterization and invitro anticancer screening of novel thiazole-1,3,4-oxadiazole hybrid analogues


The aim and objective of the work was to develop novel thiazole-1, 3, 4-oxadizole hybrid analogues and to evaluate their invitro cytotoxic activity. In this study, 9 novel thiazole-1,3,4-oxadiazole hybrid analogues were synthesized by cyclodehydrogenation reaction of 2-[(4-phenyl-1,3-thiazol-2-yl)amino]acetohydrazide with substituted aliphatic or aromatic acids using phosphorusoxychloride as dehydrating agent to yield N-[(5-substituted-1,3,4-oxadiazol-2- yl)methyl]-4-phenyl-1,3-thiazol-2-amine. The synthesized compounds were then established on the basis of IR,1HNMR spectral datas and screened for invitro anticancer activity on human breast cancer cell line MCF-7 and lymphoma cancer cell line DLA . The derivatives showed moderate activity on both cell lines.

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