It has been postulated that the development of resistance to known anti-bacterials could be overcome by identifying new drugs. Hence, the objective of the work is to improve upon the existing anti-bacterial activity of the herbal drug molecule. The main purpose is to synthesize and characterize herbo-mineral complexes and evaluate them for antibacterial activity. This research study deals with synthesis of lawsone-copper, p-coumaric acid-copper, lawsonezinc and p-coumaric acid-zinc complexes and their evaluation for anti-bacterial activity. The two herbal drugs viz. lawsone and p-Coumaric Acid were complexed with Zinc and Copper metals to form their respective complexes. The title compounds were synthesized, purified and characterized and screened against gram negative and gram positive bacteria. It can be concluded that such complexes can be utilized as novel anti-bacterial agents and check their antibacterial efficacy.